We are currently investigating the use of Haduvio™ in patients with:

• • Pruritus in Prurigo Nodularis – a chronic, intensely pruritic dermatological condition characterized by the presence of pruriginous lesions such as papules, nodules or plaques, which may be associated with excoriations and ulcerations.
  • Pruritus in Chronic Liver Disease – a common complication of chronic cholestatic liver diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC); patients develop severe whole-body itch, an intense, intractable, debilitating condition that significantly disrupts patients’ daily activities and sleep, and consequently impairs their quality of life.
  • Chronic Cough related to Idiopathic Pulmonary Fibrosis (IPF) – IPF is a rare, chronic, progressive lung disease, characterized by scarring and thickening of lung tissue; most patients diagnosed with IPF suffer from a dry, non-productive chronic cough that interrupts their daily living and significantly contributes to poor quality of life.

And are planning future clinical trials in patients with:

• • Levodopa-induced Dyskinesia (LID) in patients with Parkinson’s Disease – involuntary / motor complications resulting from levodopa therapy.

• National Institutes of Health
• American Academy of Dermatology
• European Academy of Dermatology and Venereology

 Pruritus in Chronic Liver Disease

• American Association for the Study of Liver Diseases
• The European Association for the Study of the Liver

 Chronic Cough related to Idiopathic Pulmonary Fibrosis (IPF)

• American Lung Association
• The European Idiopathic Pulmonary Fibrosis and Related Disorders Federation (EU-IPF)

Levodopa-induced Dyskinesia (LID) in patients with Parkinson’s Disease

• American Academy of Neurology
• European Academy of Neurology
• International Parkinson and Movement Disorder Society
• American Parkinson Disease Association
• The Michael J. Fox Foundation for Parkinson’s Research

You can also follow our clinical progress on the www.clinicaltrials.gov website by typing Trevi Therapeutics into the “Other terms” search box.

Interested in the PRISM Study? Click:  https://theprismstudy.com to take a short Pre-Qualifying questionnaire.

Contact your physician to inquire about clinical trials available in your area.

Randomized trials to assess the safety and efficacy of NAL ER are ongoing.  The goal of these studies is to understand the potential benefits, risks, and appropriate use(s) of NAL ER.   In order to participate, patients entering the clinical trials are required to meet specific criteria in order to protect their safety as well as the integrity of the trial. At this stage of development, Trevi considers that our current clinical trials provide the most appropriate path for patients to access the investigational medicine that we are developing.  As such, expanded access outside of the ongoing clinical trials is not currently available.